The Cardiff pitch usually offers good pace and bounce, which may prompt India to bring in experienced left-arm pacer Arshdeep Singh.
Gurnoor Brar took the wickets of Ben Duckett and Jacob Bethell in the first ODI but conceded 61 runs in his 9 overs.
Kuldeep Yadav is likely to remain on the bench if Ashdeep joins the team, while Shivam Dube and Washington Sundar are expected to retain their places after their impressive performances at Birmingham.
India: Shubman Gill (captain), Rohit Sharma, Virat Kohli, Shreyas Iyer (vice-captain), KL Rahul (WK), Ishan Kishan (WK), Washington Sundar, Axar Patel, Shivam Dube, Kuldeep Yadav, Jasprit Bumrah, Prasidh Krishna, Arshdeep Singh, Gurnoor Brar, Prince Yadav.
England: Harry Brooke (captain), Ben Duckett, Jos Buttler (wk), Tom Banton, Joe Root, Jacob Bethell, Will Jacks, Rehan Ahmed, Liam Dawson, James Coles, Sam Curran, Gus Atkinson, Jofra Archer, Jos Tonge, Saqib Mahmood, Adil Rashid.